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Applying solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the composition and dynamics of chromosomes. Our investigation interests involve:

Human Rad51 filaments on double- and solitary-stranded DNA: correlating common and irregular types with recombination purpose.

Dynamics of initiation, termination and reinitiation of DNA translocation via the motor protein EcoR124I

Non-equilibrium folding of unique DNA molecules recaptured nearly a thousand periods inside of a good condition nanopore

This yielded a breakthrough. Inside of only some months, we have been in a position to evaluate transport by way of an individual solitary-walled carbon nanotube. According to small-temperature experiments by a brilliant PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technologies by having an active exploration lab at AMOLF in Amsterdam), we showed that carbon nanotubes were authentic quantum wires with very extended (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.

Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes

What distinguishes biology from chemistry is the fact these components alongside one another make up a residing technique. The secret of claimed lifestyle, I do think, lies within the interactions, the interaction of These molecules. The massive query with regard to the origin of existence remains unanswered. How did we ever evolve from basic molecules into the really elaborate techniques we see now? We have no idea. I would like to operate on These types of large, open inquiries.’

2011, 1st in vitro measurements of transportation throughout a single biomimetic nuclear pore advanced; improvement of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the system of homology recognition in DNA homologous recombination

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one). The current–voltage curves showed significant modulations with gate voltage, even at area temperature, which was in line with band bending in a very ~0.6 eV bandgap semiconducting nanotube. These knowledge also showed the conductance can be modulated by six orders of magnitude by transforming the gate voltage. The outcomes of the work — a place-temperature transistor made from an individual carbon nanotube molecule — were released in Nature in Could 1998.

‘The idea that There may be such a factor like a starting, a major bang, is already an interesting signpost to take into account that there was a creator. But additional generally, and on the basis of pure rationality, I also arrive at a Christian interpretation of reality. An atheistic worldview is actually a ceesdekker naturalistic worldview: basically, you can find only atoms and purely natural forces that we could evaluate.

2006, 1st demonstration of molecular sorting in a lab on a chip making use of biomotors; discovery of nanobubbles in stable-point out nanopores; and initial estimate of electrokinetic Strength conversion inside of a nanofluidic channel

Visualization of unstained DNA nanostructures with Sophisticated in-emphasis transmission electron microscopy strategies

Good-point out nanopores have tested to be a surprisingly flexible probe for single-molecule analysis of DNA. I will explain many of our the latest conclusions – precisely DNA knots – and our endeavours to develop the abilities of reliable-condition nanopores even additional, within the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.